Endocrine Abstracts

Wnt/β-catenin signalling pathway is abnormally activated in most colorectal adenomas and tumours. Wnt factors are secreted glycoproteins that upon binding to their heterodimeric membrane receptors trigger a signal transduction pathway that leads to the accumulation of β-catenin in the cytosol and its nuclear translocation. Within the cell nucleus, β-catenin regulates a vast number of genes involved in cell proliferation and invasiveness via binding to members of...